VueScan uses a plugin library that's installed with the HP drivers to talk to this scanner, and doesn't work with this scanner without this plugin library. On Windows x64, you need to use VueScan x32 to use this scanner's transparency adapter. Note that HP drivers for Windows Vista or later will usually work on Windows 10. Try installing the drivers from our website, located here: LINK; Do you have administrative permissions on your computer? If you have anti-virus software installed, it's possible it may be blocking the driver installation. In your anti-virus settings, make the following directories exempt: - c:programdatakdskodak - c:windowstwain.mtx.